Table 1. Effect size (ES) data for hyperalgesia and allodynia on routine test days for control (C) and GEL (G) groups.

Effect	Ipsilateral	Contralateral	Calculated n
Hyperalgesia (Pinprick)
Last day C > G	5	23	NA
ES > 1.94 SDs	day 23–149	day 72–149	6
ES > 2.83 SDs	day 46–149	day 92–149	4
ES > 3.50 SDs	day 72–149	day 106–149	3
Allodynia (von Frey plus brush)
Last day C > G	19	149	NA
ES > 0.71 SDs	day 23–149	--	32
ES > 0.86 SDs	day 112–149	--	22
ES > 0.91 SDs	day 119–149	--	20

Included are the last day that the control group mean exceeded the GEL group mean, and the inclusive days that the size of effect for the GEL group exceeded the control group by 1.94, 2.83, or 3.50 standard deviations (SDs). ES is the difference between the group means divided by the pooled standard deviation of the two groups. The calculated n is the sample size required to detect a difference between GEL and control groups of the given size for the hyperalgesia or allodynia variable on a routine test day basis in an independent-samples t-test with 80% power and a two-sided alpha of .05. Allodynia was not consistent on the contralateral side. See routine test day means in Figure 2. NA, not applicable.