Table 1.
Lymphocyte Subpopulations
| Analysis | CM Case 1a | E57K No. 1 | E57K No. 2 | CM Case 2 | Normalb |
|---|---|---|---|---|---|
| Lymphocyte Subpopulations | |||||
| Lymph count | 330 | 1640 | 1900 | 370 | 1320–3570/µL |
| Lymph distribution | |||||
| T cells | 221 | 1260 | 1376 | 168 | 714–2266/µL |
| B cells | 30 | 335 | 397 | 187 | 59–329/µL |
| NK cells | 79 | 51 | 131 | 165 | 126–729/µL |
| T cells (%CD3+) | |||||
| TCRαβ+ | 59.1 | 73 | 67 | 17 | 56%–80% |
| TCRγδ+ | 7.8 | 4 | 6 | 15 | 0.5%–10% |
| HLA-DR% | 17.7 | 8 | 4 | 10 | 0%–20% |
| CD4+CD8− | 14.5 | 38 | 41 | 5 | 32%–62% |
| CD4−CD8+ | 45.9 | 33 | 25 | 23 | 11%–35% |
| CD4−CD8− | 5.9 | 5 | 6 | 5 | 1%–9% |
| CD62L+CD45RA+ (naive) | |||||
| (%CD4) | 23 | 62 | 53 | 20 | 14%–67% |
| (%CD8) | 34 | 69 | 67 | 10 | 25%–73% |
| CD62L+CD45RA− (CM) | |||||
| (%CD4) | 6.3 | 25 | 33 | 42 | 26%–64% |
| (%CD8) | 0 | 9 | 8 | 36 | 6%–40% |
| CD62L−CD45RA− | (EM) | ||||
| (%CD4) | 21 | 7 | 9 | 38 | 5%–30% |
| (%CD8) | 0 | 7 | 13 | 44 | 6%–34% |
| CD62L−CD45RA+ | (TEMRA) | ||||
| (%CD4) | 50 | 6 | 5 | 0 | 0%–4% |
| (%CD8) | 66 | 15 | 13 | 10 | 5%–33% |
| CD4/CD45RA/CD31% | NP | NP | NP | 1 | 2%–20% |
| CD8/CD45RA/CD31% | NP | NP | NP | 2 | 3%–18% |
| Immunoglobulin Assessment | |||||
| IgM | 183 | <21 | <21 | 72 | 34–342 mg/dL |
| IgG | 924 | 398 | 619 | 1190 | 642–1730 mg/dL |
| IgA | 285 | 26 | 43 | 84 | 91–499 mg/dL |
| IgE | 17.7 | NP | NP | 11.8 | 0.0–90.0 IU/mL |
Abbreviations: ANOVA, analysis of variance; CM, cryptococcal meningoencephalitis; EM, effector memory; Ig, immunoglobulin; NK, natural killer; NP, not performed; TEMRA, terminal effector memory expressing CD45RA.
aWe performed an ANOVA analysis finding that CM Case 1 had significantly lower total lymphocyte and T-cell counts compared with controls (P < .002 and P < .01, respectively), but further analyses were not conducted due to the small number of values in this initial case report.
bNinety-five percent range of 40 healthy volunteers.