Table 1. Participant characteristics evaluated during the baseline year.
| Total Cohort N=946 |
|
|---|---|
| Age at baseline spirometry, years, mean (SD) | 7.9 (2.0) |
| Female sex, n (%) | 470 (49.7) |
| Caucasian, n (%) | 910 (96.2) |
| Hispanic, n (%) | 31 (3.3) |
| CFTR genotype | |
| F508del homozygous, n (%) | 505 (53.4) |
| F508del heterozygous, n (%) | 358 (37.8) |
| Other/not available, n (%) | 83 (8.5) |
| History of meconium ileus, n (%) | 228 (24.1) |
| Identified by prenatal or newborn screening, n (%) | 156 (16.5) |
| Pancreatic enzyme use, n (%) | 882 (93.2) |
| Household member smokes, n (%)1 | 261 (27.6) |
| Crackles on chest exam, n (%)1 | 209 (22.1) |
| Wheeze on chest exam, n (%)1 | 110 (11.6) |
| Frequent or productive cough, n (%)1 | 545 (57.6) |
| Pulmonary exacerbation(s), n (%)1 | 186 (19.7) |
| P. aeruginosa (Pa) positive, n (%)1 | 211 (22.3) |
| Mucoid Pa positive, n (%)1 | 40 (4.2) |
| Methicillin sensitive S. aureus positive, n (%)1 | 611 (64.6) |
| Methicillin resistant S. aureus positive, n (%)1 | 168 (17.8) |
| S. maltophilia positive, n (%)1 | 137 (14.5) |
| Weight percentile2, mean (SD) | 50.0 (27.6) |
| BMI percentile2, mean (SD) | 62.7 (24.4) |
| FEV1 % predicted2, mean (SD) | 104.4 (15.5) |
1
Recorded during the baseline year only; does not include data prior to the baseline year.
2
Best value during the baseline year.