Table 3. Gametocytemia and mosquito infection among infectious patients.
Treatment Arm | Subject ID | Day of followup | Gametocytes/μL | Pfs25 RT-PCR result | Mosquitoes infected | Oocysts/mosquito, median (range) |
---|---|---|---|---|---|---|
DHP + PQ | SN-060 | 0 | 728 | + | 35/50 (70%) | 42 (1–231) |
2 | 670 | |||||
3 | 772 | 35/50 (70%) | 21(1–56) | |||
7 | 71 | + | 0/50 | |||
14 | 0 | - | 0/50 | |||
DHP only | SN-002 | 0 | 705 | + | 13/50 (26%) | 1 (1–12) |
2 | 569 | |||||
3 | 427 | 22/50 (44%) | 59 (1–147) | |||
7 | 247 | + | 37/50 (74%) | 33 (1–120) | ||
14 | 161 | + | 6/50 (12%) | 5 (1–15) | ||
SN-010 | 0 | 16 | + | 0/50 | ||
2 | 87 | |||||
3 | 71 | 22/50 (44%) | 3 (1–8) | |||
7 | 70 | + | 0/50 | |||
14 | 0 | - | 0/50 | |||
SN-063 (M*) | 0 | 690 | + | 26/30 (87%) | ||
2 | 652 | |||||
3 | 860 | 26/30 (87%) | ||||
7 | 844 | + | 27/30 (90%) | |||
14 | 250 | + | 19/30 (63%) | |||
SN-070 | 0 | 0 | + | 4/50 (8%) | 1 (1–2) | |
2 | 0 | |||||
3 | 0 | 0/50 | ||||
7 | 0 | - | 0/50 | |||
14 | 0 | - | 0/50 | |||
SN-086 | 0 | 0 | + | ?** | ||
2 | 47 | |||||
3 | 77 | 32/50 (64%) | 6 (1–34) | |||
7 | 55 | + | 33/50 (66%) | 9 (1–27) | ||
14 | 54 | + | 40/50 (80%) | 12 (1–42) | ||
SN-108 | 0 | 342 | + | 49/50 (98%) | 149 (48–398) | |
2 | 412 | |||||
3 | 375 | 49/50 (98%) | 78 (7–191) | |||
7 | 293 | + | 50/50 (100%) | 111(32–147) | ||
14 | 80 | + | 49/50 (98%) | 58 (14–132) | ||
SN-119 (M*) | 0 | 118 | + | 3/30 (10%) | ||
2 | 145 | |||||
3 | 96 | 0/30 | ||||
7 | 42 | + | 0/30 | |||
14 | 28 | - | 0/30 |
*Note that for subjects with mixed Pf/Pv infection(M), the percentage of infected mosquitoes was determined by species-specific PCR of individual mosquitoes, and oocyst counts are not reported because of inability to distinguish falciparum vs. vivax oocysts [18].
** Two of 5 and 5 of 5 pools of mosquitoes were real-time PCR positive at days 9 and 16 after feeding, respectively, but oocysts were not seen.