Table 4. ESBL-producing E. coli genes associated with the functional category virulence that are differentially expressed following exposure to CORM-2 (250 μM) versus vehicle (2.5% DMSO).

Gene	Fold change	Fold change	Gene product
symbol	First exposure	20x pre-exposed
	CORM-2 vs	CORM-2 vs
	first exposure	20x pre-exposed
	vehicle	vehicle
ibpBa	2920.4	2409.3	heat shock protein
recAb	13.6	14.2	DNA strand exchange and renaturation, DNA-dependent ATPase
ycfQ	9.9	10.6	repressor for bhsA
degP	8.2	6.2	periplasmic serine protease Do; heat shock protein HtrA
oxyR	7.5	8.8	activator, hydrogen peroxide-inducible genes
flu	7.2	7.0	outer membrane fluffing protein
rdoA	6.6	6.6	Thr/Ser kinase involved in Cpx stress response
flhE	4.8	3.3	flagellar protein flhE precursor
sat	4.7	3.3	secreted auto transporter toxin
hfq	4.6	5.0	host factor I for bacteriophage Q beta replication
flhB	2.9	3.0	putative part of export apparatus for flagellar proteins
sbmA	2.6	2.5	sensitivity to microcin B17, possibly envelop protein
dsbA	2.3	3.1	protein disulfide isomerase I
fepE	-18.5	-14.6	ferric enterobactin transport protein fepE
kpsC	-16.9	-21.7	KpsC protein
ompW	-16.4	-13.5	outer membrane protein W precursor
carA	-11.7	-22.3	carbamoyl-phosphate synthetase, glutamine
carB	-10.3	-10.6	carbamoyl-phosphate synthase large subunit
ompT	-10.1	-9.2	outer membrane protein 3b
chuT	-9.7	-14.1	putative periplasmic binding protein
iucA	-8.1	-7.3	IucA protein
serA	-7.7	-3.9	D-3-phosphoglycerate dehydrogenase
iucB	-7.1	-6.3	IucB protein
trpB	-6.9	-13.4	tryptophan synthase, beta protein
pyrD	-6.8	-10.4	dihydro-orotate dehydrogenase
fepG	-6.5	-11.1	ferric enterobactin transport protein
rfaL	-6.5	-5.6	O-antigen ligase
iucC	-6.3	-6.1	IucC protein
papX	-6.0	-8.5	PapX protein
flhD	-5.3	-7.5	regulator of flagellar biosynthesis
entA	-5.2	-6.0	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
fepC	-5.1	-5.6	ATP-binding component of ferric enterobactin transport
entB	-5.0	-6.2	2,3-dihydro-2,3-dihydroxybenzoate synthetase
evgS	-4.6	-6.4	putative sensor for regulator EvgA
entE	-4.6	-6.2	2,3-dihydroxybenzoate-AMP ligase
chuU	-4.0	-4.8	putative permease of iron compound ABC transport
chuA	-3.1	-3.7	outer membrane heme/hemoglobin receptor
csgE	-3.0	-3.3	curli production assembly/transport component
rfaP	-2.4	-2.1	lipopolysaccharide core biosynthesis

n = 4

^a also represented in defence, stress response or repair, Table 7

^b also represented in all enriched ontologies, Table 2