Figure 3.

Abl kinases regulate differential gene expression. (A) Analysis of the differential gene expression patterns between the MCF-7/c-Abl/Arg-knockdown and MCF-7/Scr samples. (B) DEGs between the 2 samples were identified by edgeR analysis. DEGs were defined as genes with a P-value ≤0.01 and a fold change ≥2 or ≤0.5. Log₁₀CPM shows the overall concentration of each compared gene in the 2 groups. (C) qRT-PCR validation of the DEGs using RNA extracted from the MCF-7/c-Abl/Arg-knockdown and MCF-7/Scr cells.