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. 2017 Jun 7;3(6):e1603081. doi: 10.1126/sciadv.1603081

Fig. 4. One-year-old knock-in animals develop ventricular arrhythmia under sedentary conditions.

Fig. 4

(A to A″) ECG tracings of 1-year-old wild-type (A) and homozygous obscurin knock-in (A′) female mice indicated that obscurin knock-in mice exhibit faster heart rate compared to wild-type mice (A″); t test, ***P < 0.001 (P = 0.00047); error bars represent SEM; wild-type, n = 4 animals; knock-in, n = 5 animals. bpm, beats per minute. (B) Knock-in but not wild-type mice exhibit frequent episodes of PVC during the 50-min monitoring period. (B′) Notably, one knock-in mouse also displayed incidents of bigeminy and trigeminy following a PVC episode. (C) An extreme case of a knock-in mouse developed spontaneous ventricular tachycardia that lasted throughout the 50-min monitoring period.