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. 2017 Jun 7;96(6):1325–1337. doi: 10.4269/ajtmh.16-0634

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©The American Society of Tropical Medicine and Hygiene

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Figure 6. — Box and whisker plot of avidity index for dengue virus types 1–4 up to 1 year post-dose 2 (adapted according-to-protocol cohort for immunogenicity). 1 μg + alum indicates participants who received 1 μg/serotype/dose adjuvanted with alum; 4 μg + alum indicates participants who received 4 μg/serotype/dose adjuvanted with alum; 1 μg + AS01_E indicates participants who received 1 μg/serotype/dose adjuvanted with AS01_E; 1 μg + AS03_B indicates participants who received 1 μg/serotype/dose adjuvanted with AS03_B. DENV = dengue virus type; PRE = prevaccination; D28 = Day 28 (1 month post-dose 1); D56 = Day 56 (1 month post-dose 2); M7 = Month 7 (6 months post-dose 2); M13 = Month 13 (12 months post-dose 2). According to the time point, the following cohorts were used to create the adapted according-to-protocol cohort for immunogenicity: for PRE, D28, D56: ATP cohort for immunogenicity D56; for M7: ATP cohort for immunogenicity M7 and for M13: ATP cohort for immunogenicity M13. Antibody avidity indices describe polyclonal antibody binding in the absence or presence of 8 M urea, as described in the Materials and Methods section. Boxes and/or whiskers with limits equal to 0 are flattened to a horizontal bar.