Table 2. Differentially Expressed Proteins of Exosomes between Healthy Control (T0) and Patients with Pancreatic Cancer (T1)a.
| Accession | Protein name | Abbreviation | normalized log2(T0/Tl) | |
|---|---|---|---|---|
| p | Mean | |||
| P80511 | Protein S100-A12 | S10AC | 0.00366 | -1.71055 |
| Q5SZB4 | Uncharacterized protein C9orf50 | CI050 | 0.02523 | -1.70237 |
| P02679 | Fibrinogen gamma chain | FIBG | 0.00315 | -1.25495 |
| P02671 | Fibrinogen alpha chain | FIBA | 0.00135 | -1.23430 |
| O15145 | Actin-related protein 2/3 complex subunit 3 | ARPC3 | 0.00411 | -1.08119 |
| P68032 | Actin, alpha cardiac muscle 1 | ACTC | 0.00874 | -1.07614 |
| P32119 | Peroxiredoxin-2 | PRDX2 | 0.00030 | -0.97950 |
| P00915 | Carbonic anhydrase 1 | CAH1 | 0.00048 | -0.97735 |
| O00187 | Mannan-binding lectin serine protease 2 | MASP2 | 0.00225 | -0.95533 |
| P00736 | Complement C1r subcomponent | C1R | 0.00222 | -0.94732 |
| Q15555 | Microtubule-associated protein RP/EB family member 2 | MARE2 | 0.00487 | -0.93202 |
| P12109 | Collagen alpha-1(VI) chain | CO6A1 | 0.00163 | -0.92449 |
| P27918 | Properdin | PROP | 0.00001 | -0.91328 |
| P12259 | Coagulation factor V | FA5 | 0.00002 | -0.91248 |
| Q15485 | Ficolin-2 | FCN2 | 0.00006 | -0.89729 |
| Q13201 | Multimerin-1 | MMRN1 | 0.00074 | -0.85019 |
| Q6E0U4 | Dermokine | DMKN | 0.02603 | -0.82876 |
| Q9H299 | SH3 domain-binding glutamic acid-rich-like protein 3 | SH3L3 | 0.00583 | -0.81949 |
| P09871 | Complement C1s subcomponent | C1S | 0.00411 | -0.80813 |
| P02763 | Alpha-1-acid glycoprotein 1 | A1AG1 | 0.01322 | -0.80272 |
| P02656 | Apolipoprotein C-III | APOC3 | 0.00650 | -0.79554 |
| P08493 | Matrix Gla protein | MGP | 0.00572 | -0.79406 |
| O75636 | Ficolin-3 | FCN3 | 0.01612 | -0.79155 |
| Q8WWZ8 | Oncoprotein-induced transcript 3 protein | OIT3 | 0.00095 | -0.78631 |
| Q4LDE5 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 | SVEP1 | 0.00778 | -0.77352 |
| P02675 | Fibrinogen beta chain | FIBB | 0.01183 | -0.77158 |
| P02776 | Platelet factor 4 | PLF4 | 0.02528 | -0.76856 |
| P02747 | Complement C1q subcomponent subunit C | C1QC | 0.04389 | -0.76156 |
| P60174 | Triosephosphate isomerase | TPIS | 0.00020 | 0.73316 |
| Q15942 | Zyxin | ZYX | 0.00052 | -0.73005 |
| P61981 | 14-3-3 protein gamma | 1433G | 0.00713 | -0.72367 |
| P69905 | Hemoglobin subunit alpha | HBA | 0.00179 | -0.72069 |
| P01042 | Kininogen-1 | KNG1 | 0.00009 | -0.71929 |
| Q08830 | Fibrinogen-like protein 1 | FGL1 | 0.00959 | -0.71273 |
| P68366 | Tubulin alpha-4A chain | TBA4A | 0.01286 | -0.69262 |
| P07195 | L-lactate dehydrogenase B chain | LDHB | 0.00495 | -0.68326 |
| P37802 | Transgelin-2 | TAGL2 | 0.00360 | -0.67952 |
| P08311 | Cathepsin G | CATG | 0.02429 | -0.67802 |
| Q16610 | Extracellular matrix protein 1 | ECM1 | 0.00921 | -0.67386 |
| P78509 | Reelin | RELN | 0.03549 | -0.66996 |
| P60709 | Actin, cytoplasmic 1 | ACTB | 0.00067 | -0.65437 |
| O15143 | Actin-related protein 2/3 complex subunit 1B | ARC1B | 0.00387 | -0.65172 |
| P18085 | ADP-ribosylation factor 4 | ARF4 | 0.04294 | -0.64543 |
| P30041 | Peroxiredoxin-6 | PRDX6 | 0.00155 | -0.63975 |
| P00488 | Coagulation factor XIII A chain | F13A | 0.00252 | -0.62313 |
| P23528 | Cofilin-1 | COF1 | 0.00524 | -0.61940 |
| P68871 | Hemoglobin subunit beta | HBB | 0.00349 | -0.61381 |
| P63104 | 14-3-3 protein zeta/delta | 1433Z | 0.00360 | -0.59736 |
| P06727 | Apolipoprotein A-IV | APOA4 | 0.04771 | -0.58892 |
| P59998 | Actin-related protein 2/3 complex subunit 4 | ARPC4 | 0.00270 | -0.58543 |
| P0CG48 | Polyubiquitin-C | UBC | 0.01690 | 0.58522 |
| P27169 | Serum paraoxanase/arylesterase 1 | PON1 | 0.00033 | 0.59535 |
| P01591 | Immunoglobulin J cahin | IGJ | 0.02380 | 0.59850 |
| P02787 | Serotranferrin | TRFE | 0.00051 | 0.62796 |
| P11226 | Mannose-binding protein C | MBL2 | 0.04009 | 0.66116 |
| Q8IWA5 | Cholin transporter-like protein 2 | CTL2 | 0.00028 | 0.66591 |
| Q8N699 | Myc target protein 1 | MYCT1 | 0.00010 | 0.66966 |
| Q99829 | Copine-1 | CPNE1 | 0.00090 | 0.67289 |
| P20851 | C4b-binding protein beta chain | C4BPB | 0.01293 | 0.67424 |
| P00751 | Complement factor B | CFAB | 0.00465 | 0.67668 |
| P48509 | CD151 antigen | CD151 | 0.03383 | 0 69911 |
| Q8NG11 | Tetraspanin-14 | TSN14 | 0.00002 | 0.70594 |
| Q8WZ42 | Titin | TITIN | 0.04448 | 0.72817 |
| Q96CX2 | BTB/POZ domain-containing protein KCTD12 | KCD12 | 0.00264 | 0.73408 |
| P01009 | Alpha-1-antitrypsin | A1AT | 0.00012 | 0.74567 |
| P00740 | Coagulation factor IX | FA9 | 0.00041 | 0.74972 |
| P02647 | Apolipoprotein A-I | APOA1 | 0.00220 | 0.75035 |
| P02652 | Apolipoprotein A-II | APOA2 | 0.00600 | 0.79768 |
| Q9UQP3 | Tenascin N | TENN | 0.00192 | 0.83012 |
| Q6GTS8 | Probable carboxypeptidase Mp20D1 | P20D1 | 0.00026 | 0.84015 |
| P22891 | Vitamin K-dependent protein Z | PROZ | 0.00652 | 0.84381 |
| Q6UX06 | Olfactomedin-4 | OLFM4 | 0.00098 | 0.84697 |
| P21926 | CD9 antigen | CD9 | 0.00087 | 0.85892 |
| O14791 | Apolipoprotein Ll | APOL1 | 0.00022 | 0.89338 |
| P28676 | Grancalcin | GRAN | 0.00012 | 0.89480 |
| P09525 | Annexin A4 | ANXA4 | 0.00000 | 0.90554 |
| P35858 | Insulin-like growth factor-binding protein complex acid labile subunit | ALS | 0.03731 | 0.91192 |
| P01019 | Angiotensinogen | ANGT | 0.00008 | 0.92375 |
| O75052 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | CAPON | 0.04511 | 0.92664 |
| P30626 | Sorcin | SORCN | 0.00005 | 0.96897 |
| P00738 | Haptoglobin | HPT | 0.00000 | 0.98060 |
| P50995 | Annexin All | ANX11 | 0.00000 | 1.00394 |
| P17936 | Insulin-like growth factor-binding protein 3 | IBP3 | 0.00753 | 1.01661 |
| P00748 | Coagulation factor XII | FA12 | 0.01941 | 1.03233 |
| O75340 | Programmed cell death protein | PDCD6 | 0.00004 | 1.03303 |
| Q5VU65 | Nuclear pore membrane glycoprotein 210-like | P210L | 0.01735 | 1.08934 |
| P20073 | Annexin A7 | ANXA7 | 0.00000 | 1.12203 |
| P08962 | CD63 antigen | CD63 | 0.00047 | 1.15061 |
| P04114 | Apolipoprotein B-100 | APOB | 0.00042 | 1.17624 |
| A6NJ16 | Putative V-set and immunoglobulin domain-containing-lik protein IGHV4OR15-8 | IV4F8 | 0.01621 | 1.18668 |
| P23069 | Genome polyprotein | POLG | 0.03860 | 1.19560 |
| P00739 | Haptoglobin-related protein | HPTR | 0.00026 | 1.21999 |
| P19652 | Alpha-1-acid glycoprotein 2 | A1AG2 | 0.00001 | 1.23090 |
| P35542 | Serum amyloid A-4 protein | SAA4 | 0.00382 | 1.28177 |
| P00742 | Coagulation factor X | FA10 | 0.00000 | 1.35757 |
| P55056 | Apolipoprotein C-IV | APOC4 | 0.00018 | 1.47476 |
| Q65900 | Genome polyprotein | POLG | 0.03128 | 1.58371 |
| Q13103 | Secreted phosphoprotein 24 | SPP24 | 0.00012 | 1.66737 |
| O75147 | Obscurin-like protein 1 | OBSL1 | 0.00130 | 2.45142 |
a
Compared with T1, 50 exosomal proteins were down-regulated and 49 were up-regulated in T0. Red and blue represent up-regulated and down-regulated, respectively.