Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 5;27(11):1685–1691.e3. doi: 10.1016/j.cub.2017.04.055

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Cortical Tuning Exerts a Complete Mediating Effect on the Relationship between GABAergic Tone and Perceptual Acuity

MRS, fMRI, and behavioral data pooled from experiments 1 and 2 (n = 22).

(A) Mediation approach applied to investigate the link between GABA concentrations (X), cortical tuning (M_i), and perceptual acuity (Y).

(B) A significant mediating effect of cortical tuning (Mi) in the relationship between GABAergic tone and perceptual acuity. The strong mediating effect of cortical tuning accounted for a considerable proportion of the total relationship between GABA and perceptual acuity (PM = 0.88; Sobel test, Z = 2.59, p = 0.0097, Preacher and Kelley κ² = 0.4651.) For full mediation statistics, see also Table S4.