Figure 2.

Morphology of Skull Substructures Are Associated with Multiple QTL

Manhattan plots for neurocranium centroid size (A) and viscerocranium PC1 GWASs (B). Red dashed line (3.6 × 10⁻⁷) indicates threshold for multiple testing with significant SNPs colored red. The associated SNPs and candidate genes at each locus are summarized in Table 1. Insets: skull schematics indicate the region of landmarks used for datasets. Expected (x axis) and observed (y axis) −log¹⁰(p) values are plotted for all SNPs (black circles) and pruned SNPs (gray circles). Histograms depict the frequency (y axis) of viscerocranium PC1 and neurocranium centroid, respectively. See also Figures S1 and S3 and Table S2.