Table 1.
Proteins most correlated with Aβ (APP) and Tau (MAPT) in the detergent-insoluble human brain proteome
| Proteins most correlated to Aβ (APP) | |||||
|---|---|---|---|---|---|
| RefSeq | Rank | Gene | Bicor | pvalue | qvalue (FDR) |
| NP_003080.2 | 1 | SNRNP70 | 0.80 | 1.01E-08 | 0.001% |
| NP_004587.1 | 2 | SNRPA | 0.69 | 5.41E-06 | 0.33% |
| NP_002501.1 | 3 | GPNMB | 0.61 | 8.96E-05 | 3.6% |
| NP_008869.1 | 4 | SNRPD1 | 0.61 | 9.01E-05 | 3.6% |
| NP_004588.1 | 5 | SNRPD2 | 0.61 | 1.10E-04 | 3.7% |
| NP_937859.1 | 6 | SNRPB | 0.60 | 1.22E-04 | 3.7% |
| NP_000257.1 | 7 | NDP | 0.59 | 1.75E-04 | 4.2% |
| NP_001630.1 | 8 | APCS | 0.58 | 3.02E-04 | 5.6% |
| NP_004166.1 | 9 | SNRPD3 | 0.55 | 6.26E-04 | 9.4% |
| NP_002066.1 | 10 | GNB3 | 0.52 | 1.27E-03 | 15.3% |
| Proteins most correlated to Tau (MAPT) | |||||
| RefSeq | Rank | Gene | Bicor | pvalue | qvalue (FDR) |
| NP_000032.1 | 1 | APOE | 0.77 | 8.65E-08 | 0.008% |
| NP_004587.1 | 2 | SNRPA | 0.74 | 2.95E-07 | 0.02% |
| NP_112487.1 | 3 | SLIRP | 0.73 | 7.54E-07 | 0.03% |
| NP_001630.1 | 4 | APCS | 0.73 | 7.82E-07 | 0.03% |
| NP_942014.1 | 5 | COL25A1 | 0.65 | 2.17E-05 | 0.68% |
| NP_002005.1 | 6 | FKBP4 | 0.61 | 1.07E-04 | 2.3% |
| NP_004386.2 | 7 | DBN1 | 0.60 | 1.28E-04 | 2.4% |
| NP_002766.1 | 8 | HTRA1 | 0.60 | 1.57E-04 | 2.7% |
| NP_001626.1 | 9 | AMPH | 0.58 | 2.78E-04 | 4.0% |
| NP_008877.1 | 10 | SPTBN2 | 0.58 | 2.78E-04 | 4.0% |