Fig. 1.

Association of differentially methylated genes with signaling pathways in responders vs nonresponders to RDN. Numbers at the end of bars indicate number of genes in the underlying pathway, filled bars indicate percentage of differentially methylated genes; green color indicates lower methylation, red color stronger methylation in the responder group. Statistical significance (p < 0.05) and, thus, non-random association of genes to pathways is indicated by the yellow curve showing − log (p-value).