Supplemental fig. 1.

Criteria for selection of methylation sites for further analysis of genes. Genes were categorized according to significance thresholds. Genes corresponding at least to the third category (p < 0.05) were considered for this publication. 6103 differentially methylated sites resulted in 1335 genes, which were used for further analysis. 479475 methylation sites were below the statistical threshold. Differences in number of methylation sites and number of genes analyzed are a result of multiple methylation sites belonging to the same gene. ß-Diff = beta-difference.