Table 2.
Differential methylation between responders and non-responders to RDN.
| Gene symbol | Encoded protein/RNA | β-Diff |
|---|---|---|
| ACE2 | Angiotensin-converting enzyme 2 | − 0.114 |
| ADRA1A | Alpha-1A adrenergic receptor | − 0.199 |
| ADRA2C | Alpha-2C adrenergic receptor | − 0.120 |
| AFF3 | AF4/FMR2 family member 3 | 0.516 |
| ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | − 0.369 |
| ARHGEF10 | Rho guanine nucleotide exchange factor 10 | − 0.103 |
| ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | − 0.177 |
| CA5B | Carbonic anhydrase 5B, mitochondrial | 0.138 |
| CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | 0.143 |
| CBX7 | Chromobox protein homolog 7 | − 0.193 |
| CCDC81 | Coiled-coil domain-containing protein 81 | 0.112 |
| CELF4 | CUGBP Elav-like family member 4 | 0.226 |
| CHM | Rab proteins geranylgeranyltransferase component A1 | 0.126 |
| CYB5B | Cytochrome b5 type B | − 0.120 |
| DNAJB6 | DnaJ homolog subfamily B member 6 | − 0.543 |
| FANCB | Fanconi anemia group B protein | 0.165 |
| FHL1 | Four and a half LIM domain protein 1 | 0.136 |
| GALNT18 | Polypeptide N-acetylgalactosaminyltransferase 18 | 0.119 |
| GPIHBP1 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 | − 0.118 |
| GYPC | Glycophorin-C | 0.135 |
| HUWE1 | E3 ubiquitin-protein ligase HUWE1 | 0.134 |
| JARID2 | Protein Jumonji | − 0.114 |
| LINC00087 | Long intergenic non-protein coding RNA 87 | 0.102 |
| LMO3 | LIM domain only protein 3 | 0.119 |
| LONRF3 | LON peptidase N-terminal domain and RING finger protein 3 | 0.132 |
| MAOA | Amine oxidase [flavin-containing] A | 0.143 |
| MXRA5 | Matrix-remodeling-associated protein 5 | − 0.160 |
| NEGR1 | Neuronal growth regulator 1 | − 0.318 |
| NKRF | NF-kappa-B-repressing factor | 0.148 |
| NMNAT3 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | − 0.309 |
| NOTCH4 | Neurogenic locus notch homolog protein 4 | 0.440 |
| PDE11A | Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A | − 0.259 |
| PDZD4 | PDZ domain-containing protein 4 | 0.107 |
| PIGA | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A | 0.110 |
| PNMA3 | Paraneoplastic antigen Ma3 | 0.283 |
| PRRG1 | Transmembrane gamma-carboxyglutamic acid protein 1 | 0.106 |
| PTGFR | Prostaglandin F2-alpha receptor | 0.184 |
| RAB1A | Ras-related protein Rab-1A | 0.225 |
| RBFOX1 | RNA binding protein fox-1 homolog 1 | 0.105 |
| RBFOX3 | RNA binding protein fox-1 homolog 3 | − 0.175 |
| SCN4B | Sodium channel subunit beta-4 | 0.248 |
| SLC39A8 | Zinc transporter ZIP8 | 0.203 |
| SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | 0.118 |
| SLC6A2 | Sodium-dependent noradrenaline transporter | − 0.147 |
| SLC7A3 | Cationic amino acid transporter 3 | 0.226 |
| SLITRK4 | SLIT and NTRK-like protein 4 | 0.142 |
| SRPX | Sushi repeat-containing protein SRPX | 0.108 |
| THBS2 | Thrombospondin-2 | − 0.115 |
| TIMP1 | Metalloproteinase inhibitor 1 | 0.135 |
| TMEM47 | Transmembrane protein 47 | 0.254 |
| TMSB15B | Thymosin beta-15B | 0.144 |
| WDR27 | WD repeat-containing protein 27 | 0.114 |
| XPNPEP2 | Xaa-Pro aminopeptidase 2 | − 0.132 |
| ZDHHC15 | Palmitoyltransferase ZDHHC15 | 0.133 |
| ZNF614 | Zinc finger protein 614 | 0.234 |
Genes showing differential methylation in responders vs nonresponders (p ≤ 0.05) and associated with hypertension according to software based analysis (p ≤ 0.05); ß-Diff = methylation (responder) − methylation (nonresponder).