Table 3.
Differential methylation of genes invovled in glutamate pathways.
| Glutamate signaling | ||
|---|---|---|
| Gene symbol | Classification | β-Diff |
| CAMK4 | Kinases | 0.110 |
| GRIA3 | AMPA receptor | 0.148 |
| GRIN2B | NMDA receptor | 0.113 |
| GRIK4 | GRIK4 | 0.145 |
| GRM8 | Class 3 metabotrope receptor | 0.113 |
| SLC1A7 | Transporter | − 0.140 |
| SLC17A7 | Transporter | 0.125 |
| Glutamate biosynthesis and degradation | ||
| GLUD1 | Glutamate dehydrogenase | 0.183 |
| GLUD2 | Glutamate dehydrogenase | 0.117 |
List of genes involved in glutamate signaling (p ≤ 0.05) or glutamate biosynthesis and degradation (p ≤ 0.005) differentially methylated in responders vs nonresponders to RDN and their classification; ß-Diff = methylation (responder) − methylation (nonresponder).