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. 2017 Jun 7;7:2980. doi: 10.1038/s41598-017-03354-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed protein-coding genes in PDAC. (A) Heatmap of the 1,887 differentially expressed transcript clusters in PDAC. The heatmap represents relative over- (red) and under-expressed (green) genes. The covariates at the top represent tumour (red) and normal (blue) samples. A subgroup of 11 PDAC samples is indicated by the orange box, determined by the exocrine-like gene signature by Collisson et al. with higher expression in a cluster of 255 transcripts than other PDAC samples. (B) KEGG pathway enrichment test for significantly up- and down-regulated genes in PDAC. The BH adjusted p-values were used (x-axis). (C) Heatmap and sample clustering based on the Collisson signature dividing samples into three molecular subtypes.