Table 3.
Univariate and multivariate analysis of poor prognostic factors for OS in APC patients.
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Gender | ||||||
| Male | 0.988 | 0.673–1.452 | 0.952 | |||
| Female | ||||||
| Age | ||||||
| <60 | 0.876 | 0.609–1.259 | 0.475 | |||
| ≥60 | ||||||
| ECOG PS | ||||||
| 2 | 2.011 | 1.233–3.280 | 0.005 | 1.524 | 0.886–2.261 | 0.128 |
| 0–1 | ||||||
| Primary tumor location | ||||||
| Head and neck | 1.375 | 0.948–1.996 | 0.093 | |||
| Body and tail | ||||||
| TNM stage | ||||||
| IV | 2.163 | 1.415–3.307 | <0.001 | 1.762 | 1.121–2.771 | 0.014 |
| III | ||||||
| Liver metastasis | ||||||
| Yes | 1.999 | 1.382–2.891 | < 0.001 | |||
| No | ||||||
| Chemotherapy | ||||||
| Gemcitabine monotherapy | 0.831 | 0.573–1.207 | 0.331 | |||
| Others | ||||||
| CRP (mg/L) | ||||||
| ≥5 | 1.793 | 1.245–2.580 | 0.002 | |||
| <5 | ||||||
| Albumin (g/L) | ||||||
| ≥35 | 0.553 | 0.354–0.866 | 0.010 | |||
| <35 | ||||||
| CAR | ||||||
| ≥0.156 | 2.004 | 1.389–2.891 | <0.001 | 1.629 | 1.097–2.419 | 0.016 |
| <0.156 | ||||||
| GPS | ||||||
| 2 | 1.539 | 1.201–1.971 | 0.001 | |||
| 1 | ||||||
| 0 | ||||||
| mGPS | ||||||
| 2 | 1.437 | 1.121–1.844 | 0.004 | |||
| 1 | ||||||
| 0 | ||||||
| AST (IU/L) | ||||||
| ≥40 | 1.560 | 1.059–2.297 | 0.024 | 0.937 | 0.604–1.453 | 0.771 |
| <40 | ||||||
| ALT (IU/L) | ||||||
| ≥40 | 1.087 | 0.713–1.658 | 0.697 | |||
| <40 | ||||||
| CA19–9 (U/ml) | ||||||
| ≥1000 | 1.989 | 1.359–2.911 | <0.001 | 1.973 | 1.332–2.924 | 0.001 |
| <1000 | ||||||
| CEA (ng/ml) | ||||||
| ≥5 | 1.380 | 0.948–2.010 | 0.092 | |||
| <5 | ||||||
| Hemoglobin (g/L) | ||||||
| <120 | 0.887 | 0.618–1.274 | 0.516 | |||
| ≥120 | ||||||