Table 2.
Genotypes of TLR3 rs3775291, TLR4 rs4986790, TLR9 rs187084, and TLR10 rs4129009 encoding genes in relation to asthma and allergy at preschool age in 135 former bronchiolitis patients.
| Asthma ever | Current asthma | Current atopic dermatitis | Current allergic rhinitis | |
|---|---|---|---|---|
| TLR3 rs3775291 N = 135 | N = 37 | N = 18 | N = 46 | N = 39 |
| Wild CC N = 62 (%) | 19 (30.6) | 8 (12.9) | 20 (32.3) | 16 (25.8) |
| Variant CT, TT N = 73 (%) | 18 (24.7) p = 0.45 | 10 (13.7) p = 0.55 | 26 (35.6) p = 0.72 | 23 (31.5) p = 0.57 |
| TLR4 rs4986790 N = 135 | N = 37 | N = 18 | N = 46 | N = 39 |
| Wild AA N = 113 (%) | 31 (27.4) | 16 (14.2) | 39 (34.5) | 34 (30.1) |
| Variant AG, GG N = 22 (%) | 6 (27.3) p = 1.00 | 2 (9.1) p = 0.74 | 7 (31.8) p = 1.00 | 5 (22.7) p = 0.61 |
| TLR9 rs187084 N = 134 | N = 37 | N = 18 | N = 46 | N = 39 |
| Wild TT N = 43 (%) | 11 (25.6) | 4 (9.3) | 10 (23.3) | 13 (30.2) |
| Variant TC, CC N = 91 | 26 (28.0)p = 0.44 | 14 (15.4) p = 0.25 | 36 (40.0) p = 0.06 | 26 (28.6) p = 0.50 |
| TLR10 rs4129009 N = 134 | N = 37 | N = 18 | N = 46 | N = 39 |
| Wild AA N = 113 (%) | 28 (24.8) | 12 (10.6) | 39 (34.5) | 31 (27.4) |
| Variant AG, GG N = 21 (%) | 9 (42.9) p = 0.08 | 6 (28.6) p = 0.03 | 7 (33.3) p = 0.57 | 8 (38.1) p = 0.23 |