Table 3.
Genotypes of TLR7 rs179008 and TLR8 rs2407992 encoding genes in relation to asthma and allergy at preschool age in 135 former bronchiolitis patients.
| Asthma ever | Current asthma | Current atopic dermatitis | Current allergic rhinitis | |
|---|---|---|---|---|
| TLR7 rs179008 Females N = 66 | N = 14 | N = 8 | N = 23 | N = 17 |
| Wild AA N = 40 (%) | 5 (12.5) | 3 (7.5) | 15 (37.5) | 10 (25.0) |
| Variant AT, TT N = 26 (%) | 9 (34.6) p = 0.03 | 5 (19.2) p = 0.25 | 8 (30.8) p = 0.61 | 7 (27.0) p = 1.00 |
| TLR8 rs2407992 Females N = 66 | N = 14 | N = 8 | N = 23 | N = 17 |
| Wild GG N = 23 (%) | 5 (21.7) | 2 (8.7) | 8 (34.8) | 5 (21.7) |
| Variant GC, CC N = 43 (%) | 9 (20.9) p = 1.00 | 6 (14.0) p = 0.70 | 15 (32.6) p = 1.00 | 12 (26.1) p = 0.77 |
| TLR7 rs179008 Males N = 68 | N = 23 | N = 10 | N = 23 | N = 22 |
| Wild, allele A present N = 54 (%) | 18 (33.3) | 7 (13.0) | 19 (35.2) | 19 (35.2) |
| Variant, allele T present N = 14 (%) | 5 (37.5) p = 1.00 | 3 (21.4) p = 0.68 | 3(21.4) p = 0.76 | 3 (21.4) p = 0.36 |
| TLR8 rs2407992 Males N = 69 | N = 23 | N = 10 | N = 23 | N = 22 |
| Wild, allele G present N = 35 (%) | 11 (31.4) | 6 (17.1) | 12 (34.3) | 13 (37.1) |
| Variant, allele C present N = 34 (%) | 12 (35.3) p = 0.80 | 4 (11.8) p = 0.73 | 11 (32.4) p = 1.00 | 9 (26.5) p = 0.44 |
TLR7 and TLR8 are presented separately for females and males. One test result of a TLR7 male presented AT heterozygote and was deleted from the analyses.