Table 3.
Genotype distribution and allele frequency of estrogen receptor-α gene polymorphisms in patients with osteoarthritis and control individuals
| Groups | ER-α genotypes | ER-α alleles | |||||||
| OA (%) | Control (%) | Pa | OA (%) | Control (%) | Pb | OR (95% CI) | |||
| PvuII (T/C) | TT | 61 (40.4) | 152 (38.3) | 0.89 | T | 190 (62.9) | 487 (61.3) | 0.63 | 0.93 (0.71–1.23) |
| CT | 68 (45.0) | 183 (46.1) | |||||||
| CC | 22 (14.6) | 62 (15.6) | C | 112 (37.1) | 307 (38.7) | ||||
| XbaI (A/G) | AA | 98 (64.9) | 256 (64.5) | 0.81 | A | 245 (81.1) | 638 (80.3) | 0.77 | 0.95 (0.68–1.33) |
| AG | 49 (32.4) | 126 (31.7) | |||||||
| GG | 4 (2.70) | 15 (3.80) | G | 57 (18.9) | 156 (19.7) | ||||
| BtgI (G/A) | GG | 84 (55.6) | 257 (64.7) | 0.13 | G | 225 (74.5) | 636 (80.1) | 0.044 | 1.38 (1.01–1.88) |
| GA | 57 (37.8) | 122 (30.7) | |||||||
| AA | 10 (6.60) | 18 (4.60) | A | 77 (25.5) | 158 (19.9) | ||||
A total of 151 patients with osteoarthritis (OA) and 397 control individuals were included in the study. aControl individuals versus patients using the χ2 test with 3 × 2 contingency table. bControl individuals versus patients using the χ2 test with 2 × 2 contingency table. CI, confidence interval; ER, estrogen receptor; OR, odds ratio.