. 2004 Jul 19;6(5):R415–R421. doi: 10.1186/ar1207

Table 5.

Comparison of estrogen receptor-α gene haplotypes in osteoarthritis patients and control individuals

Haplotype	Controls			OA patients

	Total	Women	Men	Total	Women	Men

TAG	0.41	0.44	0.37	0.41	0.42	0.40
TAA	0.09	0.12	0.05	0.17	0.18	0.14
TGG	0.09	0.09	0.08	0.05	0.05	0.05
TGA	0.03	0.03	0.02	<0.01	<0.01	<0.01
CAG	0.25	0.18	0.31	0.18	0.18	0.18
CAA	0.06	0.06	0.06	0.05	0.04	0.07
CGG	0.06	0.06	0.08	0.10	0.10	0.09
CGA	0.02	0.01	0.02	0.04	0.02	0.07
				df = 7, χ²= 21.48; P^a= 0.003	df = 7, χ²= 8.22; P^a= 0.314	df = 7, χ²= 16.76; P^a= 0.019

A total of 397 control individuals and 151 osteoarthritis (OA) patients were included in the study. Values given are haplotype frequencies. ^aP values for overall difference in haplotype distribution between OA patients and control individuals were calculated using the EH program [23]. df, degrees of freedom.