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. 2017 Jun 7;7:2999. doi: 10.1038/s41598-017-02871-1

Figure 5.

Figure 5

A subject with COPD staged at baseline with GOLD-2 (first column) with 5-year follow-up (second column) revealing a progression to GOLD-3. No substantial change in %PRMfSAD was detected (first row), however a striking drop in Local SfSAD was found (second row). This demonstrates a potential pattern of progression, with diffuse disease coalescing into more focal distribution.