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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2017 Mar 19;109:75–83. doi: 10.1016/j.freeradbiomed.2017.03.020

Figure 2. Structural Features and Sites of Post-Translational Regulation of the Human MKP-1 Protein.

Figure 2

The N-terminal domain of MKP-1 is responsible for both nuclear localization, driven by a leucine-rich nuclear localization sequence (NLS), and for binding of MAPK through its specific arginine-rich kinase binding domain (KBD). The highly-conserved C-terminal domain of MKP-1 contains the catalytic domain and its active site sequence (CS) that catalyzes the dephosphorylation of tyrosine/threonine residues of target substrates.