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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2017 Mar 19;109:75–83. doi: 10.1016/j.freeradbiomed.2017.03.020

Table 1.

Inducers of MKP-1 Expression

Inducer Cell Type/Tissue mRNA/Protein Effect/Function References
Glucocorticoid Endothelial cell, macrophages mRNA Inflammation ↓ [72–74]
Vitamin D Monocytes, macrophages mRNA Inflammation ↓ [75, 76]
Curcumin Hippocampal cells Protein Ethanol-induced toxicity ↓ [71]
Ursolic acid Monocytes Protein Metabolic stress-induced priming ↓ [70]
Nitroalkenes Macrophages mRNA Inflammation ↓ [64]
VEGF Endothelial cell mRNA Migration ↓ [77]
Thrombin Endothelial cell mRNA Activation ↓ [78]
Atrial natriuretic peptide (ANP) Endothelial cell mRNA Activation ↓ [78, 79]
Retinoids Mesangial cells mRNA Apoptosis ↓ [80]
Trichostatin A, HDAC inhibitor Macrophages Protein Osteoclastogenesis ↓ [81]
Rapamycin, mTOR inhibitor Macrophages mRNA Inflammation ↓ [82]
Clozapine Frontal cortex (rat) mRNA Psychotic action ↓ [83]
High molecular weight hyaluronic acid (HA) Chondrocytes Protein MMP production ↓ [84]
ETYA, peroxisome proliferator-activated receptor (PPAR)-α activator Astrocytes mRNA Inflammation ↓ [85]
Rolipram (PDE4 inhibitor) Macrophages mRNA Inflammation ↓ [86]