Table 1.
Risk of All-cause mortality in Hodgkin Lymphomaa: Multivariable Analysis Stratified by Treatment Site (CCC/COGb vs. Non-CCC/COG Facilities)
| Age Group | Gender | Stage | Race/Ethnicity e | Insurance + Socioeconomic Status (SES) | Treatment Site | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1–29y | 30–39y | Female | Male | Localized | Regional | Remote | NHW | AA/Hisp | API | Private + High SES | Public/None + Mid/Low SES | CCC/COG | Non-CCC/COG | ||
| Treated at NCI-Designated Comprehensive Cancer Center or Children’s Oncology Group site | |||||||||||||||
| Model 1 | HR (95%CI) |
1.0 | 0.7 (0.1–5.9) |
1.0 | 2.6 (0.5–13.3) |
1.0 | 0.4 (0.1–2.4) |
0.1 (0.01–1.5) |
|||||||
| p-value | – | 0.7 | – | 0.3 | – | 0.3 | 0.1 | ||||||||
| Model 2 | HR (95%CI) |
1.0 | 0.7 (0.1–7.9) |
1.0 | 2.6 (0.5–13.5) |
1.0 | 0.5 (0.1–2.5) |
0.2 (0.01–1.7) |
1.0 | 1.1 (0.2–5.8) |
– e | ||||
| p-value | – | 0.8 | – | 0.3 | – | 0.4 | 0.1 | – | 0.9 | – | |||||
| Model 3 | HR (95%CI) |
1.0 | 0.7 (0.1–7.2) |
1.0 | 2.6 (0.5–13.7) |
1.0 | 0.5 (0.1–2.6) |
0.2 (0.01–1.7) |
1.0 | 1.1 (0.2–5.8) |
– e | 1.0 | 0.6 (0.1–4.2) |
||
| p-value | – | 0.8 | 0.3 | – | 0.4 | 0.1 | – | 0.9 | – | – | 0.6 | ||||
| Not Treated at NCI-Designated Comprehensive Cancer Center or Children’s Oncology Group site | |||||||||||||||
| Model 1 | HR (95%CI) |
1.0 |
2.1 (1.4–3.3) |
1.0 |
2.0 (1.2–3.1) |
1.0 | 0.9 (0.4–2.0) |
2.1 (1.0–4.3) |
|||||||
| p-value | – | <0.001 | – | 0.005 | – | 0.8 | 0.04 | ||||||||
| Model 2 | HR (95%CI) |
1.0 |
2.1 (1.4–3.4) |
1.0 |
2.0 (1.3–3.2) |
1.0 | 1.0 (0.5–2.2) |
2.3 (1.1–4.6) |
1.0 |
1.7 (1.1–2.6) |
0.5 (0.1–1.9) |
||||
| p-value | – | <0.001 | – | 0.003 | – | 1.0 | 0.03 | – | 0.03 | 0.3 | |||||
| Model 3 | HR (95%CI) |
1.0 |
2.2 (1.4–3.4) |
1.0 |
2.0 (1.3–3.2) |
1.0 | 1.0 (0.5–2.2) |
2.3 (1.1–4.6) |
1.0 |
1.6 (1.0–2.5) |
0.5 (0.1–1.9) |
1.0 | 1.2 (0.6–2.5) |
||
| p-value | – | <0.001 | 0.004 | – | 1.0 | 0.03 | – | 0.05 | 0.3 | – | 0.6 | ||||
Cox regression multivariable analysis adjusted for variables denoted above in addition to lymphoma stage and gender.
CCC/COG: NCI-Designated Comprehensive Cancer Center or Children’s Oncology Group site
Hazard Ratios (HR) with 95% Confidence Intervals (CI).
Bolded values represent statistically significant findings, p<0.05
Patients of all race/ethnicity categories were included in analyses performed on the full cohort as well as the stratified analysis performed in non-CCC/COG patients; API patients were excluded from the CCC/COG stratified analysis as there were no events at CCC/COG sites for these patients (n=12).