Table 2.
Replication analyses and final meta-analysis of discovery and replication stages
| PGC replication (N=20,171) |
HRS replicatio n (N= 8,157) |
Overall replication (N=28,328) |
Meta-analysis of discovery & two replication samples (N= 98,345) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr:BP | Allel e |
Direc t.a |
P | Direc t. |
P | Direct .b |
P | MA F |
Direc t.c |
z- scor e |
P |
| rs98258 23 |
3:61,082,1 53 |
T/C | +++−− ++−+− ++−− ++ |
0.0 4 |
+ | 0.2 | ++ | 0.0 2 |
0.4 6 |
+++ | 6.10 | 1.0×1 0−9 |
| rs93234 97 |
14:67,873, 128 |
T/C | +−+−−− − ++++− −−++ |
0.8 | − | 0.8 | +− | 0.9 | 0.0 5 |
−++ | 4.61 | 4.0×1 0−6 |
Chr: Chromosome, BP: base pair, MAF: minor allele frequency (GRCh37/hg19), Direct=Direction. Allele: Minor/Major on the + strand.
Order of the studies: The Cognitive Function and Mood Study (CoFaMS), The PsyCoLaus Study, MDD2000-Edinburgh, GENPOD/NewMeds, Depression Genes Networks, GenRED2, Harvard i2b2, Janssen, The Marx Planck Institute of Psychiatry (MPIP) Munich Antidepressant Response Signature (MARS) Study OMNIex, QIMR COEX, Radiant Irish, Radiant US Cases, Radiant Denmark Cases, Roche, SHIP Trend, TwinGene.
Order of the studies: PGC- replication Health and Retirement Study.
Order of the studies: PGC-replication, Health and Retirement Study, combined meta-analysis of discovery samples.