Table 2.

All Grade 3-4 AEs and Other AEs Occurring in > 20% of Patients

	Adverse Event	Grade 1	Grade 2	Grade 3	Grade 4
Constitutional	Fatigue	5 (39%)	4 (31%)	2 (15%)	0 (0%)
	Pain	6 (46%)	6 (46%)	0 (0%)	0 (0%
	Fall	0 (0%)	0 (0%	1 (8%)	0 (0%)
	Other Constitutional	3 (23%)	2 (15%)	0 (0%)	0 (0%)
Vascular	Hypertension	0 (0%)	2 (15%)	2 (15%)	0 (0%)
	Headache	5 (39%)	1 (8%)	1 (8%)	0 (0%)
	Intracranial Hemorrhage	0 (0%)	0 (0%	1 (8%)	0 (0%)
Gastrointestinal	GERD	2 (15%)	3 (23%)	1 (8%)	0 (0%)
	Constipation	2 (15%)	2 (15%)	0 (0%)	0 (0%)
	Diarrhea	8 (62%)	2 (15%)	0 (0%)	0 (0%)
	Anorexia	4 (31%)	1 (8%)	0 (0%)	0 (0%)
	Weight Loss	4 (31%)	0 (0%)	0 (0%)	0 (0%)
	Dysgeusia	5 (39%)	2 (15%)	0 (0%)	0 (0%)
	Nausea / Emesis	6 (46%)	0 (0%)	0 (0%)	0 (0%)
	Emesis	4 (31%)	0 (0%)	0 (0%)	0 (0%)
	Other GI	2 (15%)	3 (23%)	0 (0%)	0 (0%)
Skin	Stomatitis	0 (0%)	0 (0%)	1 (8%)	0 (0%)
	Rash	4 (31%)	1 (8%)	1 (8%)	0 (0%)
	Hand Foot Syndrome	2 (15%)	1 (8%)	0 (0%)	0 (0%)
	Dry Mouth	4 (31%)	0 (0%)	0 (0%)	0 (0%)
	Other Skin	6 (46%)	2 (15%)	0 (0%)	0 (0%)
Genitourinary	Bladder Spasms	0 (0%)	3 (23%)	0 (0%)	0 (0%)
	Other Urinary	7 (54%)	1 (8%)	0 (0%)	0 (0%)
Infection	Fever	4 (31%)	0 (0%)	0 (0%)	0 (0%)
	Infection	0 (0%)	8 (62%)	0 (0%)	0 (0%)
Pulmonary	Hoarseness	3 (23%)	0 (0%)	0 (0%)	0 (0%)
	Other Pulmonary	4 (31%)	1 (8%)	0 (0%)	0 (0%)
Musculoskeletal	Arthralgia / Myalgia	4 (31%)	2 (15%)	0 (0%)	0 (0%)
Metabolic	Hypertriglyceridemia	1 (8%)	2 (15%)	1 (8%)	1 (8%)
	Elevated Alkaline Phosphatase	2 (15%)	1 (8%)	0 (0%)	0 (0%)
	Elevated GGT	0 (0%)	1 (8%)	2 (15%)	0 (0%)
	Hypoalbuminemia	2 (15%)	1 (8%)	0 (0%)	0 (0%)
	Elevated Lipase	0 (0%)	0 (0%)	2 (15%)	0 (0%)
	Other Metabolic	6 (46%)	0 (0%)	0 (0%)	0 (0%)
Hematologic	Anemia	4 (31%)	0 (0%)	0 (0%)	0 (0%)

(AE = Adverse Event)