Table 2.
Comparisons of cerebral blood flow levels in different brain regions between NCs and patients in the ON or OFF states.
| MNI atlas coordinates |
Voxel size | Region | tmax | ||
|---|---|---|---|---|---|
| X | Y | Z | |||
| NC > PDOFF (Palpha < 0.05; Puncorrected was 0.001 with a cluster size >155 voxels) | |||||
| 40 | 35 | 33 | 211 | R middle frontal gyrus (BA 9) | 4.52 |
| –51 | –24 | –20 | 638 | L inferior temporal gyrus (BA 20) | 4.37 |
| –58 | –12 | –20 | – | L middle temporal gyrus (BA 21) | 4.07 |
| 3 | 57 | 0 | 198 | R medial frontal gyrus (BA 10) | 4.34 |
| –2 | 36 | 48 | 214 | L superior frontal gyrus (BA 8) | 4.29 |
| 2 | 21 | –17 | 236 | R subcallosal gyrus (BA 25) | 4.23 |
| 8 | 32 | –15 | – | R anterior cingulate (BA 24) | 4.04 |
| NC > PDON (Palpha < 0.05; Puncorrected was 0.001 with a cluster size >155 voxels) | |||||
| 3 | 22 | –15 | 408 | R anterior cingulate (BA 25) | 5.76 |
| 39 | 22 | –20 | 190 | R inferior frontal gyrus (BA 47) | 5.56 |
| 50 | 8 | –2 | 720 | R insula (BA 13) | 5.34 |
| 57 | 6 | –17 | – | R superior temporal gyrus (BA 38) | 4.78 |
| –2 | 52 | –14 | 171 | L anterior cingulate (BA 32) | 5.17 |
| –3 | 58 | –3 | – | L medial frontal gyrus (BA 10) | 4.42 |
| –63 | –19 | 28 | 189 | L inferior parietal lobe (BA 40) | 4.87 |
| –57 | –31 | 18 | – | L superior temporal gyrus (BA 42) | 3.43 |
| –2 | 14 | 34 | 232 | L cingulate gyrus (BA 24) | 4.85 |
| –62 | –12 | –21 | 2,104 | L inferior temporal gyrus (BA 21) | 4.83 |
| –66 | –22 | –20 | – | L inferior temporal gyrus (BA 20) | 4.64 |
| –68 | –25 | –9 | – | L middle temporal gyrus (BA 21) | 4.57 |
| –40 | 0 | 45 | 241 | L precentral gyrus (BA 6) | 4.74 |
| 46 | 39 | 10 | 867 | R middle frontal gyrus (BA 46) | 4.64 |
| 44 | 48 | 13 | – | R middle frontal gyrus (BA 10) | 4.42 |
| 21 | 6 | 61 | 171 | R middle frontal gyrus (BA 6) | 4.54 |
| –38 | 17 | 6 | 325 | L insula (BA 13) | 4.54 |
| 24 | 48 | 30 | 173 | R superior frontal gyrus (BA 9) | 4.49 |
| 56 | –34 | 24 | 267 | R insula (BA 13) | 4.48 |
| 60 | –24 | 31 | – | R inferior parietal lobe (BA 40) | 3.72 |
| 40 | 5 | 43 | 223 | R middle frontal gyrus (BA 6) | 4.48 |
| 44 | –57 | 24 | 298 | R middle temporal gyrus (BA 39) | 4.43 |
| –28 | 29 | 52 | 187 | L middle frontal gyrus (BA 6) | 4.27 |
| –36 | –21 | 4 | 159 | L claustrum | 4.21 |
| –45 | –12 | 4 | – | L insula (BA 13) | 3.63 |
| –50 | –42 | 52 | 223 | L inferior parietal lobe (BA40) | 4.13 |
| 62 | –27 | –6 | 391 | R middle temporal gyrus (BA 21) | 4.13 |
| 62 | –25 | 3 | – | R superior temporal gyrus (BA 22) | 4.02 |
| 56 | –30 | –17 | – | R inferior temporal gyrus (BA 20) | 3.45 |
| 57 | –49 | 12 | 218 | R superior temporal gyrus (BA 22) | 4.11 |
| 52 | –54 | 22 | – | R superior temporal gyrus (BA 39) | 3.53 |
| 45 | 44 | 27 | 349 | R superior frontal gyrus (BA 9) | 4.07 |
| 46 | 14 | 34 | – | R precentral gyrus (BA 9) | 3.88 |
| 50 | 14 | 21 | – | R inferior frontal gyrus (BA 9) | 3.61 |
| 36 | –3 | 6 | 181 | R claustrum | 4 |
| PDOFF > PDON (Puncorrected < 0.05, cluster size >100) | |||||
| –38 | –61 | –50 | 353 | L cerebellar tonsil | 4.2 |
| –30 | 11 | 57 | 215 | L middle frontal gyrus (BA 6) | 4.2 |
| –9 | –1 | –18 | 131 | L subcallosal gyrus (BA 34) | 3.88 |
BA, Brodmann area; MNI, Montreal Neurological Institute; NC, normal control; PD, Parkinson’s disease; R, right; L, left.