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. 2017 Jun 8;10:180. doi: 10.3389/fnmol.2017.00180

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Copyright © 2017 Sarowar, Grabrucker, Boeckers and Grabrucker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RICH2 KO mice display no neophobia in response to odors. (A) Mice were exposed to water (control), banana, and almond (test) odors for 10 min. Odors were introduced in similar spots as objects in the open field and the response of mice assessed (B). (C) No significant difference in the distance traveled (p = 0.5308 for water, p = 0.5045 for banana, p = 0.2682 for almond, unpaired t-test), the number of transitions (D) (p = 0.5078 for water, p = 0.4687 for banana, p = 0.1036 for almond, unpaired t-test), the entries into object zones (E) (p = 0.2797 for water, p = 0.6869 for banana, p = 0.2288 for almond, unpaired t-test) and time spent in object zones (F) (p = 0.8350 for water, p = 0.9398 for banana, p = 0.6450 for almond, unpaired t test) was detected between RICH2 KO mice and WT in response to novel odors (n = 5 for each group).