Table 1.
Association of ATM gene polymorphisms with lung cancer.
| Gene | Genotype | Cases N (%) | Controls N (%) | Crude odds ratio (OR) (95% CI) | Adjusted odds ratiosa (95% CI) |
|---|---|---|---|---|---|
| ATM (rs227060) | 352 | 451 | |||
| CC | 137 (38.9) | 183 (40.6) | 1.00 | 1.00 | |
| CT | 150 (42.6) | 213 (47.2) | 0.94 (0.69–1.28) | 0.93 (0.68–1.28) | |
| TT | 65 (18.5) | 55 (12.2) | 1.58 (1.04–2.41) | 1.52 (0.99–2.35) | |
| Dominant model | CT + TT | 215 (61.1) | 268 (59.4) | 1.07 (0.81–1.43) | 1.06 (0.79–1.42) |
| Recessive model (ref: CC + CT) | TT | 65 (18.5) | 55 (12.2) | 1.63 (1.10–2.41) | 1.58 (1.06–2.35) |
| Allele OR | T | 1.18 (0.96–1.44) | 1.16 (0.94–1.42) | ||
| ATM (rs228589) | 360 | 448 | |||
| TT | 103 (28.6) | 127 (28.4) | 1.00 | 1.00 | |
| TA | 150 (41.7) | 222 (49.6) | 0.83 (0.60–1.16) | 0.81 (0.57–1.14) | |
| AA | 107 (29.7) | 99 (22.0) | 1.33 (0.91–1.94) | 1.31 (0.89–1.94) | |
| Dominant model | TA + AA | 257 (71.4) | 321 (71.7) | 0.99 (0.73–1.34) | 0.96 (0.70–1.32) |
| Recessive model (ref: TT + TA) | AA | 107 (29.7) | 99 (22.0) | 1.49 (1.09–2.05) | 1.50 (1.08–2.08) |
| Allele OR | A | 1.15 (0.95–1.39) | 1.14 (0.94–1.38) |
Estimates in bold represent statistically significant associations.
aAdjusted for age, sex, and smoking status (0 = never smokers, 1 = ever smokers).