Table 2.
Association of combined genotypes of ATMrs227060, ATMrs228589, and p53rs1042522 with lung cancer.
| No. of risk genotypes | ATMrs227060 | ATMrs228589 | p53rs1042522 | Cases N (%) | Controls N (%) | Crude odds ratio (95% CI) | Adjusted odds ratiosa (95%CI) |
|---|---|---|---|---|---|---|---|
| 333 | 441 | ||||||
| 0 | CC + CT | TT + TA | GG + GC | 173 (52.0) | 272 (61.7) | 1.00 | 1.00 |
| 1 | CC + CT | AA | GG + GC | 92 (27.6) | 108 (24.5) | 1.34 (0.96–1.88) | 1.39 (0.98–1.96) |
| CC + CT | TT + TA | CC | |||||
| TT | TT + TA | GG + GC | |||||
| 2 | CC + CT | AA | CC | 53 (15.9) | 54 (12.2) | 1.54 (1.01–2.36) | 1.49 (0.97–2.31) |
| TT | AA | GG + GC | |||||
| TT | TT + TA | CC | |||||
| 3 | TT | AA | CC | 15 (4.5) | 7 (1.6) | 3.37 (1.35–8.43) | 3.68 (1.43–9.45) |
| p for trend | 0.002 | 0.002 | |||||
Estimates in bold represent statistically significant associations; p values in bold represent statistically significant linear trend.
aAdjusted for age, sex, and smoking status (0 = never smokers, 1 = ever smokers).