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Illustration of mechanistic action of quercetin in L6 myotubes. Quercetin pretreatment in L6 myotubes enhanced AMP to ATP ratio which resulted in a transient change in mitochondrial membrane potential. There was also an associated increase in intracellular calcium level, which resulted in the activation of AMPK and its downstream target P38MAPK. Akt was also upregulated pointing to the conclusion that quercetin follows AMPK pathway, and it overlaps with insulin signaling pathway.
