Figure 2.

Injury-induced neurogenesis in the adult fly brain. (A) Traumatic brain injury paradigm in Drosophila: Stab lesions are performed with a thin metal filament to injure the right optic lobe (ROL). (B) Scheme depicting the retina and neuropils of the optic lobe. The eye is lesioned to the level of the medulla. La, Lamina; Med, Medulla; L, Lobula; Lop, Lobular plate. (C) Injury leads to activation and proliferation of quiescent adult neural progenitor cells, which give rise to new neurons, likely involving generation of a type of intermediate proliferating cell (IPC). SC, Stem cells.