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. 2017 Jun 8;8:358. doi: 10.3389/fphar.2017.00358

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Copyright © 2017 Woillard, Mourad, Neely, Capron, van Schaik, van Gelder, Lloberas, Hesselink, Marquet, Haufroid and Elens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visual predictive check (VPC) of simulated concentrations (dashed lines) represented by the 10th, 50th, and 90th percentiles versus time with the mean observed Tac concentrations (solid line) and the individual values (dots).