Table 2.

Pharmacokinetic parameters of the structural and the final models.

Parameters	TPV Mean	[CI95%]
Structural Model
C0	2.61	[2.13–3.08]
a1	15.70	[8.548–22.91]
b1	22.09	[10.30–33.89]
a2	16.62	[10.22–23.02]
b2	5.40	[0.95–9.85]
r	0.51	[0.46–0.57]
F∗AIV	21.09	[17.69–24.49]
alpha	1.51	[1.19–1.82]
Final model
C0	2.94	[2.42–3.47]
a1	12.33	[6.25–18.41]
b1	20.36	[7.37–33.35]
a2	15.19	[9.46–20.91]
b2	5.05	[1.02–9.08]
r	0.46	[0.40–0.51]
F∗AIV	24.52	[20.61–28.43]
alpha	1.52	[1.19–1.85]
𝜃CY P3A	0.77	[0.74–0.80]

C₀ = the model estimated Tac trough level for a theoretical dose of 1000 mg (the real trough level can be calculated by dividing this value by 1000 and multiplying by the patient dose) (a_i,b_i) = parameters of the gamma distributions, r = the fraction of dose absorbed following the first gamma function, F = bioavailability coefficient, A_IV = initial blood concentration obtained after a bolus IV injection, 𝜃_CYP3A = parameter representing the effect of the CYP3A covariate on the typical value of the Tac blood concentrations. For more details, see Supplemental Data 1. alpha = elimination parameter.