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. 2017 Jun 8;8:1027. doi: 10.3389/fmicb.2017.01027

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Copyright © 2017 Hassan, Maldonado, dos Santos, Di Lorenzo, Silipo, Coutinho, Cooper, Molinaro, Valvano and Sá-Correia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic organization of gene clusters for core-lipid A and OAg biosynthesis in B. cenocepacia IST439 (A) and the reference strains K56-2 and J2315 (B). The flanking genes ureG and apaH are indicated in black and the four genes represented in gray encode proteins putatively involved in lipid A-core biosynthesis. The genes in dark-red correspond to genes present in IST439 without a counterpart in the reference strain J2315 (Supplementary Figure S3), but with a degree of homology to B. multivorans ATCC 17616 (see also Supplementary Figure S4B). The red-vertical arrows above the genes represent the two non-synonymous point mutations in genes bmul_2510 and wbiI of the 10 sequential isolates (comparative genomic analysis to be described elsewhere). A GC content plot is also represented for IST439 [drawn using Artemis (Carver et al., 2008)] above the display line of the sequence, where the genes annotated as B. multivorans are highlighted in a black rectangle. wλ, 3-deoxy-D-manno-octulosonic acid transferase; kdoO, Kdo dioxygenase; waaC, heptosyltransferase I; manB, phosphomannomutase; wzx, OAg exporter; wbxA, glycosyltransferase; wbxB, glycosyltransferase; galE, UDP-glucose epimerase; wecA, UDP-N-acetylglucosamine 1-P transferase; wbiI, nucleotide sugar epimerase-dehydratase; wbiH, UDP-N-acetylglucosamine 1-P transferase; wbiG, nucleotide sugar epimerase-dehydratase; wbiF, glycosyltransferase; bmul_2508, conserved hypothetical protein; Bmul_2509, group 1 glycosyl transferase; Bmul_2510, conserved hypothetical protein; Bmul_2514, type 11 methyltransferase; wzt, ABC transporter ATP-binding protein; wzm, ABC transporter membrane permease; rmlDCAB, dTDP-rhamnose biosynthesis; wbxC, acetyltransferase; wbxD, glycosyltransferase; wbxE, glycosyltransferase; vioA, nucleotide sugar aminotransferase.