Table 2.
Multinomial logistic regression analysis of the association of BMI with different combinations of cardiometabolic disease, adjusted for age, sex and ethnic origin (total n=104 730)
| Vascular disease only (n=5214) | Vascular disease followed by diabetes (n=415) | Diabetes only (n=5596) | Diabetes followed by vascular disease (n=598) | |
|---|---|---|---|---|
| <20·0 kg/m2 (underweight) | 0·9 (0·7–1·0) | 1·1 (0·5–2·2) | 0·7 (0·5–0·9) | 0·5 (0·2–1·4) |
| 20·0–24·9 kg/m2 (healthy weight) | 1·0 (reference) | 1·0 (reference) | 1·0 (reference) | 1·0 (reference) |
| 25·0–29·9 kg/m2 (overweight) | 1·2 (1·1–1·3) | 2·4 (1·8–3·1) | 3·3 (3·0–3·6) | 3·1 (2·4–4·1) |
| 30·0–34·9 kg/m2 (obese, class I) | 1·5 (1·3–1·6) | 4·9 (3·6–6·7) | 9·4 (8·6–10·3) | 8·5 (6·4–11·2) |
| ≥35·0 kg/m2 (obese, classes II and III) | 2·2 (1·9–2·6) | 12·0 (8·1–17·9) | 18·6 (16·6–20·9) | 29·8 (21·7–40·8) |
| Continuous BMI, per 5 units | 1·3 (1·2–1·3) | 2·3 (2·1–2·6) | 2·7 (2·6–2·7) | 2·9 (2·7–3·2) |
Data are odds ratio (95% CI). In the Americans' Changing Lives Study (ACL), the British Health and Lifestyle Survey (HALS), the National Survey of Midlife Development in the United States (MIDUS), and the United Kingdom Household Panel Survey (UKHLS), the order of disease onset could not be determined. 6227 participants developed vascular disease (3924 had coronary heart disease, 1816 stroke, and 487 had both) and 6609 were diagnosed with diabetes. Vascular disease followed by diabetes refers to participants with coronary heart disease or stroke who subsequently developed comorbid diabetes. Diabetes followed by vascular disease refers to participants with diagnosed diabetes who subsequently developed comorbid coronary heart disease or stroke.