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. 2017 Jun 8;7:242. doi: 10.3389/fcimb.2017.00242

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Copyright © 2017 Zhang, Liao, Gao, Wang, Wang, Li, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasmid analysis of pGZ2-NDM and pGZ3-NDM. Structure map of pGZ2-NDM and pGZ3-NDM (A) and comparative analysis of the genetic contexts of bla_NDM-5 in plasmids reported in this study and previously described (B). The gene name is shown next to the corresponding arrow or rod. Genetic regions with dashed lines in pGZ2-NDM and pGZ3-NDM are indicated as bla_NDM-5 region. The genetic environment of bla_NDM-5 (with dashed line) in pGZ2-NDM and pGZ3-NDM was similar as that previously described in pNDM-QD28 (GenBank accession KU167608.1) and pCQ02-121 (GenBank accession KU647721.2) with 100% query coverage and 99% identity. However, the regions containing bla_NDM-5 were inserted into different genes and plasmid backbones.