TABLE 2.
Association of Thromboembolic Disease in First-degree Relatives of Index Placental Abruption Cases and Controls
| First-degree Relatives | Abruption Cases (n = 212) |
Controls (n = 206) |
Odds Ratio (95% Confidence Interval) |
|||
|---|---|---|---|---|---|---|
| Total Members | Thromboembolic Diseasea No. (%) | Total Members | Thromboembolic Diseasea No. (%) | Unadjusted OR (95% CI) | Adjustedb OR (95% CI) | |
| All relativesc | 852 | 64 (7.5) | 792 | 38 (4.8) | 1.6 (1.1, 2.4) | 1.6 (1.0, 2.5) |
| Parents | 358 | 56 (15.6) | 329 | 35 (10.6) | 1.6 (1.0, 2.5) | 1.5 (0.9, 2.5) |
| Siblings | 494 | 8 (1.6) | 463 | 3 (0.7) | 2.5 (0.7, 9.6) | 2.6 (0.7, 9.7) |
| Female relatives | 446 | 32 (7.2) | 438 | 13 (3.0) | 2.5 (1.3, 4.9) | 2.6 (1.3, 5.0) |
| Biologic mother | 188 | 26 (13.8) | 170 | 12 (7.1) | 2.1 (1.0, 4.3) | 2.0 (1.0, 4.2) |
| Full sisters | 258 | 6 (2.3) | 268 | 1 (0.4) | 6.4 (0.8, 53.2) | 6.8 (1.8, 25.7) |
| Male relatives | 406 | 32 (7.9) | 354 | 25 (7.1) | 1.1 (0.7, 1.9) | 1.1 (0.6, 1.9) |
| Biologic father | 170 | 30 (17.1) | 159 | 23 (14.5) | 1.3 (0.7, 2.3) | 1.3 (0.7, 2.3) |
| Full brothers | 236 | 2 (0.9) | 195 | 2 (1.0) | 0.8 (0.1, 5.9) | 0.7 (0.2, 3.9) |
a
Thromboembolic disease among male relatives includes one or more of myocardial infarction, embolism, stroke, deep-vein thrombosis, and blood clots and restricted to relatives ≤65 years old.
b
Associations were adjusted for subjects’ age, smoking status, and race.
c
Analysis for “all relatives” were further adjusted for sex.