Table 4.
Cox hazard regression model
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI 95% | P | HR | CI 95% | P | |
| Exposure time (<5 vs. >5 year) | 1.59 | 0.94–2.69 | 0.09 | – | – | ns |
| Adjunctive risk factors (yes vs. no) | 1.04 | 0.59–1.80 | 0.90 | – | – | ns |
| Number of risk factors | – | – | 0.81 | – | – | ns |
| (1 vs. 0) | 1.12 | 0.62–2.02 | 0.72 | |||
| (>1 vs. 0) | 0.90 | 0.44–1.85 | 0.78 | |||
| Therapy | – | – | 0.56 | – | – | ns |
| HU versus no | 1.20 | 0.62–2.34 | 0.59 | |||
| ALK versus no | 0.53 | 0.11–2.45 | 0.41 | |||
| ALK+HU versus no | 0.73 | 0.27–1.92 | 0.52 | |||
| ANA/IFN versus no | 0.64 | 0.14–2.88 | 0.56 | |||
| Sex (male vs. female) | 1.74 | 1.06–2.87 | 0.03 | 1.7 | 1.04–2.82 | 0.03 |
| Age (>60 vs. <60 years) | 4.21 | 2.32–7.64 | <0.0001 | 4.19 | 2.32–7.61 | <0.0001 |