Table 1.
Clinical characteristics and prevalence of ALP elevation at diagnosis
| Variables | n (%) | ALP at diagnosis | |||
|---|---|---|---|---|---|
| Elevation n (%) | Normal n (%) | NA n | P | ||
| Survival | |||||
| 5‐year Survival | 116 (55.2) | 49 (43.0) | 65 (57.0) | 2 | 0.000 |
| DOD | 67 (31.9) | 50 (78.1) | 14 (21.9) | 3 | |
| CDF <5 years | 12 (5.7) | ||||
| NED | 1 (0.5) | ||||
| AWD | 3 (1.4) | ||||
| DOC | 11 (5.2) | ||||
| Metastasis rate | |||||
| Positive | 70 (37.4) | 43 (64.2) | 24 (35.8) | 3 | 0.001 |
| Free | 117 (62.6) | 46 (39.3) | 71 (60.7) | 0 | |
| Stage | |||||
| Localized | 187 (89.0) | 89 (47.6) | 94 (50.3) | 4 | 0.000 |
| Metastatic | 23 (11.0) | 20 (90.9) | 2 (9.1) | 1 | |
| Age | 20.5 (3–71)a | ||||
| ≥15 | 131 (62.4) | 71 (55.5) | 57 (44.5) | 3 | 0.395 |
| <15 | 79 (37.6) | 38 (49.4) | 39 (50.6) | 2 | |
| Sex | |||||
| Male | 117 (55.7) | 73 (64.0) | 41 (35.0) | 3 | 0.000 |
| Female | 93 (44.3) | 36 (38.7) | 55 (59.1) | 2 | |
| Size | |||||
| ≥ 8 cm | 132 (68.0) | 79 (62.2) | 48 (37.8) | 5 | 0.000 |
| < 8 cm | 62 (32.0) | 20 (32.3) | 42 (67.7) | 0 | |
| NA | 16 | ||||
| Location | |||||
| Extremity | 185 (88.1) | 93 (51.7) | 87 (48.3) | 5 | 0.247 |
| Axial and proximal femur | 25 (11.9) | 16 (64.0) | 9 (36.0) | 0 | |
| Histologic grade | |||||
| Low | 20 (9.5) | 3 (15.0) | 17 (85.0) | 0 | 0.000 |
| High | 190 (90.5) | 106 (57.3) | 79 (42.7) | 5 | |
| Histology (High grade) | |||||
| Conventional | |||||
| Osteoblastic | 88 (58.7) | 55 (63.2) | 32 (36.8) | 1 | 0.008b |
| Chondroblastic | 18 (12.0) | 8 (44.4) | 10 (55.6) | 0 | |
| Fibroblastic | 7 (4.7) | 0 (0.0) | 7 (100.0) | 0 | |
| Mixed | 24 (16.0) | 12 (54.5) | 10 (45.5) | 2 | |
| Nonconventional | 13 (8.7) | 5 (35.8) | 8 (61.5) | 0 | |
| NA | 42 | ||||
| Huvos grade | |||||
| I and II | 52 (32.7) | 32 (64.0) | 18 (36.0) | 2 | 0.158 |
| III and IV | 107 (67.3) | 54 (51.9) | 50 (48.1) | 3 | |
| NA | 27 | ||||
| No chemotherapy | 24 | ||||
|
Surgery (Operability) | |||||
| Operable | 197 (93.8) | 98 (51.0) | 94 (49.0) | 5 | 0.019 |
| Inoperable | 13 (6.2) | 11 (84.6) | 2 (15.4) | 0 | |
| Resection margin | |||||
| R0 | 182 (92.4) | 89 (50.0) | 89 (50.0) | 4 | 0.303 |
| R1 and R2 | 15 (7.6) | 9 (64.3) | 5 (35.7) | 1 | |
| Pathologic fracture | |||||
| Yes | 12 (5.7) | 4 (33.3) | 8 (66.6) | 0 | 0.156 |
| No | 198 (94.3) | 105 (54.4) | 88 (45.6) | 5 | |
| Intracapsular extension | |||||
| Yes | 38 (22.8) | 18 (48.6) | 19 (51.4) | 1 | 0.732 |
| No | 139 (77.2) | 71 (51.8) | 66 (48.2) | 2 | |
| NA | 33 | ||||
| ALP At diagnosis | 109 (53.2) | 96 (46.8) | 5 | ||
| ALP at 1st metastasisc | |||||
| Elevation | 33 (53.2) | 22 (73.3) | 8 (26.7) | 3 | 0.086 |
| Normal | 29(46.8) | 15 (51.7) | 14 (48.3) | 0 | |
| NA | 8 | ||||
ALP, Alkaline Phosphatase; NA, Not Available; DOD, Died of Disease; CDF, Continuously Disease Free; NED, No Evidence of Disease; AWD, Alive with Metastatic Disease; DOC, Died of Other Cause; R0, Negative Resection Margin; R1, Microscopically Positive Resection Margin; R2, Macroscopically Positive Resection Margin.
a
Mean(minimum‐maximum).
b
Calculated using Fisher`s exact test.
c
63 pulmonary metastasis and 7 local recurs.