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. 2017 May 23;6(6):1240–1254. doi: 10.1002/cam4.1083

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© 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Topotecan is a potent drug when used against IMR‐3, SK‐N‐SH and LAN‐1 neuroblastoma cell lines. Dose‐response curves for topotecan (panel A) were determined in neuroblastoma cell lines using PrestoBlue^® as described in the Methods. The IC ₅₀ for the drugs are indicated. Changes in LAN‐1 cell viablity as a function of different topotecan exposure times (panel B) were determined. The IC ₅₀ as a function of topotecan exposure time for each cell line are summarized in panel C. Results are compared to untreated controls and presented as the mean ± SD of at least three independent experiments performed in triplicate.