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Effect of the S. paranense crude extract (a), S. paranense alkaloid fraction (b), solanine (c), and dexamethasone (Dexa) administered topically on croton oil-induced acute ear edema. Each bar represents the mean + SEM (n = 6); ###P < 0.001 when compared with the vehicle (acetone) group. ∗∗∗P < 0.001 when compared with the croton oil group (one-way ANOVA followed by post hoc Newman-Keuls test).
