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Flow chart of the drug administration. (a) Control group: water only. (b) PMR group: PMR only. (c) CYP1A2 inhibitor control group: cimetidine only. (d) CYP2E1 inhibitor control group: trans-1,2-dichloroethylene only. (e) CYP1A2 inhibitor + PMR group: cimetidine and PMR. (f) CYP2E1 inhibitor + PMR group: trans-1,2-dichloroethylene and PMR.
