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Metabolic elimination percentage of two probe substrates, phenacetin (for CYP1A2) and chlorzoxazone (for CYP2E1). (a) Control group; (b) PMR group; (c) CYP1A2 inhibitor control group; (d) CYP2E1 inhibitor control group; (e) CYP1A2 inhibitor and PMR group; (f) CYP2E1 inhibitor and PMR group (shown as mean SD, n = 5; ∗significant difference compared with the control group, P < 0.05; ∗∗extremely significant difference compared with the control group, P < 0.01).
