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. 2017 Apr 9;8(7):1145–1152. doi: 10.7150/jca.18026

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RNAs expression in serum and exosomes derived from colon cancer patients. A: Mass spectrometry show the peaks of RNAs in exosomes are small RNAs. B: The content of small-molecule RNAs in exosomes is significantly higher than in fresh serum (The figure above shows the peak of small RNAs in fresh serum of colon cancer patients; the figure below shows the peak of small RNAs in exosomes derived from the same serum). C: There are still a little of small-molecule RNAs in no-exosome serum, but significantly lower than the content of RNAs in exosomes (The figure above shows the content of small RNAs in exosomes; the figure below shows the content of small RNAs in exosome-free serum). D: No RNA was detected in repeated freezing and thawing serum, but in the exosomes extracted from repeated freezing and thawing serum, there are still certain levels of RNAs. (The figure above shows the content of small RNAs in repeated freezing and thawing serum; the figure below shows the content of small RNAs in exosome extracted from repeated freezing and thawing serum.)