Table 1.
Relevant patient characteristics according to study group
| Variables | Unmatched group | Matched group | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All patients (n = 1,723) |
non-PMX-HP (n = 1,201) |
PMX-HP (n = 522) |
SD | P value | All patients (n = 524) |
non-PMX-HP (n = 262) |
PMX-HP (n = 262) |
SD | P value | |
| Age, years | 69.7 (13.8) | 69.5 (14.0) | 70.0 (13.1) | 0.036 | 0.502 | 69.9 (13.1) | 70.3 (13.4) | 69.4 (12.8) | 0.070 | 0.422 |
| Male, n (%) | 1019 (59.1) | 705 (58.7) | 314 (60.2) | 0.030 | 0.574 | 304 (58.0) | 150 (57.3) | 154 (58.8) | 0.031 | 0.723 |
| Body weight, kg | 56.6 (14.1) | 56.6 (14.5) | 56.6 (13.4) | 0.007 | 0.903 | 56.5 (14.6) | 56.0 (14.4) | 57.0 (14.8) | 0.064 | 0.465 |
| Emergency center ICU, n (%) | 729 (42.3) | 486 (40.5) | 243 (46.6) | 0.123 | 0.019 | 239 (45.6) | 121 (46.2) | 118 (45.0) | 0.023 | 0.793 |
| Admission route to the ICU, n (%) | ||||||||||
| Emergency department | 735 (42.7) | 543 (45.2) | 192 (36.8) | 0.172 | 0.000 | 215 (41.0) | 109 (41.6) | 106 (40.5) | 0.023 | 0.790 |
| Other hospital | 423 (24.6) | 287 (23.9) | 136 (26.1) | 0.050 | 0.339 | 121 (23.1) | 62 (23.7) | 59 (22.5) | 0.027 | 0.756 |
| Hospital ward | 565 (32.8) | 371 (30.9) | 194 (37.2) | 0.133 | 0.011 | 188 (35.9) | 91 (34.7) | 97 (37.0) | 0.048 | 0.585 |
| ICU policy, n (%) | ||||||||||
| Open ICU | 549 (31.9) | 387 (32.2) | 162 (31.0) | 0.026 | 0.628 | 160 (30.5) | 74 (28.2) | 86 (32.8) | 0.100 | 0.255 |
| Closed ICU | 897 (52.1) | 637 (53.0) | 260 (49.8) | 0.065 | 0.217 | 281 (53.6) | 147 (56.1) | 134 (51.1) | 0.100 | 0.255 |
| Others | 277 (16.1) | 177 (14.7) | 100 (19.2) | 0.118 | 0.022 | 83 (15.8) | 41 (15.6) | 42 (16.0) | 0.011 | 0.905 |
| Number of ICU beds, number | 12 (8–18) | 12 (10–19) | 10 (7–12) | 0.429 | <0.001 | 10.5 (8–16) | 12 (8–15) | 10 (7–16) | 0.041 | 0.361 |
| Pre-existing organ dysfunction, n (%) | ||||||||||
| Liver insufficiency | 83 (4.8) | 49 (4.1) | 34 (6.5) | 0.109 | 0.032 | 30 (5.7) | 12 (4.6) | 18 (6.9) | 0.099 | 0.262 |
| Chronic respiratory disorder | 66 (3.8) | 46 (3.8) | 20 (3.8) | 0.000 | 1.000 | 18 (3.4) | 6 (2.3) | 12 (4.6) | 0.126 | 0.158 |
| Chronic heart failure | 99 (5.7) | 68 (5.7) | 31 (5.9) | 0.012 | 0.821 | 29 (5.5) | 13 (5.0) | 16 (6.1) | 0.050 | 0.567 |
| Chronic hemodialysis | 149 (8.6) | 99 (8.2) | 50 (9.6) | 0.047 | 0.365 | 53 (10.1) | 25 (9.5) | 28 (10.7) | 0.038 | 0.664 |
| Immunocompromised | 299 (17.4) | 218 (18.2) | 81 (15.5) | 0.070 | 0.185 | 83 (15.8) | 43 (16.4) | 40 (15.3) | 0.031 | 0.720 |
| None | 1,108 (64.3) | 773 (64.4) | 335 (64.2) | 0.004 | 0.941 | 338 (64.5) | 177 (67.6) | 161 (61.5) | 0.128 | 0.145 |
| Severity | ||||||||||
| APACHE II score | 25.4 (8.9) | 25.2 (8.9) | 25.9 (8.9) | 0.083 | 0.115 | 25.2 (9.2) | 25.5 (8.9) | 25.0 (9.5) | 0.060 | 0.493 |
| SOFA score | 11.5 (3.5) | 11.2 (3.5) | 12.0 (3.5) | 0.246 | <0.001 | 11.6 (3.4) | 11.7 (3.4) | 11.5 (3.4) | 0.067 | 0.442 |
| SIRS positivea, n (%) | 1,654 (96.0) | 1151 (95.8) | 503 (96.4) | 0.027 | 0.611 | 499 (95.2) | 253 (96.6) | 246 (93.9) | 0.126 | 0.157 |
| JAAM DIC positiveb, n (%) | 1,092 (63.4) | 723 (60.2) | 369 (70.7) | 0.222 | <0.001 | 345 (65.8) | 176 (67.2) | 169 (64.5) | 0.056 | 0.519 |
Data are presented as mean (standard deviation), median (first quartile to third quartile), or number (percentage)
aSIRS criteria ≥2
bJAAM DIC score ≥4
APACHE Acute Physiology and Chronic Health Evaluation, DIC disseminated intravascular coagulation, ICU intensive care unit, JAAM Japanese Association for Acute Medicine, PMX-HP polymyxin B hemoperfusion, SD standardized difference, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment