TABLE 2.
Clinical Performance of p16INK4a Immunochemistry as Evaluated by Nonpathologist Readers and a Pathologist to Identify Women With Histologic Diagnosis of CIN2 or More Severe Diagnoses (CIN2+)
| Reader result
|
Pathologist result
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | YI | PLR | Sensitivity (%) | Specificity (%) | YI | PLR | |
| Reader 1 | 96 | 96 | 92 | 24 | 96 | 96 | 92 | 24 |
| Reader 2 | 96 | 80 | 76 | 4.8 | 96 | 88 | 84 | 8.0 |
| Reader 3 | 88 | 88 | 76 | 7.3 | 96 | 88 | 84 | 8.0 |
| Reader 4 | 72 | 96 | 68 | 18 | 96 | 96 | 92 | 24 |
| Reader 5 | 92 | 76 | 68 | 3.8 | 96 | 88 | 84 | 8.0 |
| Reader 6 | 96 | 84 | 80 | 6.0 | 96 | 96 | 92 | 24 |
| Reader 7 | 96 | 84 | 80 | 6.0 | 96 | 88 | 84 | 8.0 |
| Reader 8 | 96 | 84 | 80 | 6.0 | 96 | 88 | 84 | 8.0 |
| Reader 9 | 76 | 88 | 64 | 6.3 | 96 | 96 | 92 | 24 |
| Reader 10 | 92 | 88 | 80 | 7.7 | 96 | 88 | 84 | 8.0 |
| Reader 11 | 76 | 92 | 68 | 9.5 | 96 | 96 | 92 | 24 |
| Reader 12 | 84 | 88 | 72 | 7.0 | 96 | 96 | 92 | 24 |
| Mean/Overalla | 88 | 87 | 75 | 6.8 | 96 | 92 | 88 | 12 |
YI, Youden Index (= sensitivity + specificity − 1); PLR, positive likelihood ratio.
a
The average performance of all reads for all tissues was calculated. The pathologist read all slides only once and the overall performance is presented.