Table 1.
Reduced expression of histone deacetylases in 3D GSC compared with 2D GSC
| Gene | Locus |
Log2_fold
2D v 3D |
Cell Line |
Significance
(P value) |
|---|---|---|---|---|
| HDAC5 | chr17:42154120-42201014 | −0.28206 | G7 | .02705 |
| HDAC6 | chrX:48660486-48683380 | −0.24577 | G7 | .0224 |
| HDAC7 | chr12:48166966-48213763 | −0.61262 | G7 | 5.00E-05 |
| −0.53918 | E2 | .03 | ||
| HDAC9 | chr7:18126571-19036992 | −0.84383 | G7 | .00065 |
| −0.8634 | E2 | 5.00E-05 |
Source: RNA sequencing (RNA-Seq) analysis of gene expression performed on G7 and E2 cells grown on plastic (2D) or 3D- Alvetex scaffolds (3D).